Equipoise in Clinical Trials-Djulbegovich

Working with researchers at the University of South Florida CSR designed and fielded this vignette-based factorial web survey to investigate whether clinical trials could be identified where the interests of trial patients and future patients come into balance or "equipoise." Deployed on a customized website hosted by CSR the web survey presented each expert respondent--recruited from Institutional Review Board members at the 122 U.S. American Association of Medical Colleges (AAMC) schools--with four pairs of randomized clinical trial vignettes followed by a ninth "bonus" vignette of a type that matched one of the previous four pairs. In each of the nine vignettes seven aspects of each scenario could be randomly varied resulting in over 1 000 possible variations covering different phases of hypothetical clinical trials involving rheumatoid arthritis and pancreatic cancer patients.
Sample
Nationwide sample of members of Institutional Review Boards at university Medical Schools. Supplementary sample drawn from membership list of PRIM&R (association of professionals in human subjects issues).
Principal Investigators
Tom Guterbock
Client Name
Ben Djulbegovich MD
Sponsor
University of South Florida (funds from the Bankhead-Coley Cancer Research Program)
Project ID
9.21
Year
2009